|
KMID : 0363620230440030029
|
|
Journal of Korean Oriental Medicine
2023 Volume.44 No. 3 p.29 ~ p.38
|
|
|
Acute toxicity study of 77 herbal formulas according to GLP guidelines in rats
|
|
Shin Hyeun-Kyoo
Jeon Woo-Young
Seo Chang-Seob
Lee Mee-Young
|
|
|
Abstract
|
|
|
Objectives : This study aimed to investigate the acute oral toxicity of 77 herbal formulas and performed in male and female Sprague-Dawley (SD) rats as per the guidelines mentioned in Ministry of Food and Drug Safety.
Methods : Each sex of SD rat were administered a single dose (2000 or 5000 mg/kg) of 77 herbal formulas via oral gavage; the control group received vehicle only. After administration, the mortality, clinical signs, gross findings, and body weight were followed up for 15 days.
Results : After administration of 77 herbal formulas, mortality, clinical signs, body weight changes, and gross findings related to the test substances were not observed in both male and female groups.
Conclusion : Our results demonstrate the single-dose oral administration of 77 herbal formulas produced no mortality indicating the approximate lethal dose is greater than 2000 or 5000 mg/kg body weight.
|
|
|
KEYWORD
|
|
|
Herbal formulas, Acute toxicity, Good Laboratory Practice, approximate lethal dose
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|